Research Position for SimCardioTest Project (post-doc or pre-doc) at Universitat Politecnica Valencia

The Cardiac Modeling Group belongs to the Electronics Engineering Department of the Polytechnical University of Valencia (UPV), Spain. The group is integrated by 5 faculty members and a variable number of post-doctoral and PhD students. We seek two highly motivated candidate (predoctoral or postdoctoral) to develop computational multiscale personalized models of the electrical activity of the heart to enable the in silico testing of drug efficacy and safety under healthy and pathological conditions.

The group has ample experience in modeling and simulating the electrical activity of the heart. Throughout our cardiac simulation work, we have developed and analyzed cardiac action potential (AP) models of different tissues (atrium, ventricle, and Purkinje) and different animal species (dog, rabbit, guinea pig, and human) under normal and under several pathological conditions, such as ischemia, heart failure, atrial fibrillation, and mutations. The group also has valuable experience in modeling the effects of drugs on different ionic channels. Moreover, we have developed computational tools for the simulation of the electrophysiological activity of a variety of tissue structures (unicellular, one-dimensional, bi-dimensional and tri-dimensional).

The candidate will develop cellular to 3D cardiac personalized models to simulate the effects of drugs on the electrical activity of the heart. Methods of image processing and mathematical modeling will be used to achieve the objectives. The candidate will receive data from our collaborators from the clinical and pharmaceutical field to build realistic and personalized models, as well as population of models considering variability and uncertainty.

CONTRACT DETAILS:

Applications: February 2022 Initial date: March-April 2022 Duration: 3 years at full and exclusive dedication.

QUALIFICATIONS:

• PhD in in Engineering, Mathematics or Physics will be highly valued.
• Master Degree in Biomedical Engineering, Applied Mathematics, Physics, other Engineering degrees or related discipline with strong numerical components focusing on mathematical modeling, simulation, and image processing.
• Training and/or experience in mechanistic modeling of electrophysiological systems is preferred.
• Understanding of ordinary and partial differential equations and how these can be applied in the development of complex models of electrophysiological models.
• In-depth, hands-on knowledge of modeling and simulation software (MATLAB, C/C++, Fortran).
• Keen interest in learning new computational skills.
• Self-directed with ability to work independently.
• Excellent communication and writing skills in English.
• Keen interest in living in the sunny Valencia.