A recent publication in Nature Biotech explains how genome-scale network reconstructions have helped uncover the molecular basis of metabolism.
This article written by Brunk et al presents Recon3D, a computational resource that includes three-dimensional (3D) metabolite and protein structure data and enables integrated analyses of metabolic functions in humans.
Recon3D is used to functionally characterize mutations associated with disease, and identify metabolic response signatures that are caused by exposure to certain drugs.
Recon3D represents the most comprehensive human metabolic network model to date, accounting for 3,288 open reading frames (representing 17% of functionally annotated human genes), 13,543 metabolic reactions involving 4,140 unique metabolites, and 12,890 protein structures. These data provide a unique resource for investigating molecular mechanisms of human metabolism.
Further information can be found at http://vmh.life.
Here the link to the article
